Document 0602
 DOCN  M95A0602
 TI    A clinical staging system to predict survival of infants with
       perinatally acquired HIV infection. American Pediatric Society 104th
       annual meeting and Society for Pediatric Research 63rd annual meeting;
       1994 May 2-5; Seattle.
 DT    9510
 AU    Forsyth BW; O'Conner T; Andiman WA; Yale University, Department of
       Pediatrics, New Haven, CT, USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330442
 AB    Information concerning prognosis and survival of HIV-infected infants
       should be helpful in clinical decision making and stratification for
       clinical trials. The purpose of this study was to develop a clinical
       staging system to be used in infancy to predict survival of HIV-infected
       children. We reviewed the clinical course of 75 children with
       perinatally acquired HIV infection born between 1979 and 1992 and
       followed to June 1993. All children were followed beginning in infancy.
       Of the 31 subjects who died, 23 died before age 3 yrs. Subjects were
       classified at various ages in infancy according to clinical findings and
       risk of death by age 3 yrs: those with clinical findings associated with
       high risk (R.R. > 3, P < .01) were categorized as stage 4; moderate risk
       (R.R. > 2, P < .05), stage 3; slight risk (R.R. > 1.5, P = N.S.), stage
       2; and no increased risk, stage 1. Stage 4 includes encephalopathy, PCP
       and other opportunistic infections, stage 3 includes oral candidiasis,
       serious bacterial infections and persistent fever and stage 2 includes
       hepatomegaly and FTT. At each age in infancy (6, 9 and 12 months)
       survival curves were significantly different (P < .001) for subjects in
       different stages except stages 1 and 2 were similar. For example, at 9
       months the median survival for stages 4, 3 and 2 + 1 were 1.1, 6.2 and
       9.6 yrs. respectively. This staging system is likely to be helpful
       clinically and in stratifying subjects for clinical trials.
 DE    Child, Preschool  *Disease Transmission, Vertical  Human  HIV
       Infections/COMPLICATIONS/*MORTALITY/TRANSMISSION  Infant  Prognosis
       Survival Rate  MEETING ABSTRACT  JOURNAL ARTICLE

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