Document 0606
 DOCN  M95A0606
 TI    HIV infection and neonatal & maternal characteristics. American
       Pediatric Society 104th annual meeting and Society for Pediatric
       Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Fuchs G; Tienboon P; Sirivatanapa P; Sirisanthana V; Ruangyuttikarn C;
       Suskind R; RIHES, Chiang Mai University, Thailand.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330438
 AB    Thirty HIV seropositive mother-infant pairs were retrospectively
       studied. Maternal gestational weight gain, infant birthweight, and
       ultimate confirmed HIV infection status of the infants were reviewed.
       Mean gestational age of all infants was 39 weeks +/- 2.3, and mean
       birthweight 2923 g +/- 433. Seventeen percent of infants were low
       birthweight (LBW) (< 2500 g) and 10% were born large for gestational age
       (LGA) (> 3500 g). The mean birth length was 48.0 cm +/- 2.1. Of all
       infants seropositive at birth, 14 (47%) were ultimately documented to be
       infected. Maternal nutritional status as measured by prenatal weight
       increase or body mass index did not correlate with the development of
       HIV infection in the infant. Two of thirteen (15%) infected infants and
       5 of 16 (31%) of noninfected infants were born prematurely. The mean
       birthweight of HIV-infected infants was 2942 g +/- 377 compared to 2906
       g +/- 488 of HIV-noninfected infants (P = 0.82). Of the 27 infants with
       birth length measurements, the mean birth length of the 12 HIV-infected
       infants was 48.2 cm +/- 1.8 compared to that of HIV-noninfected infants
       47.8 cm +/- 2.3 (p = 0.63). Two of 14 infected infants (14%) and 3/16
       (19%) noninfected infants were LBW. Of the infants born to the 12 women
       who were also VDRL seropositive, half were ultimately determined to be
       HIV-infected. Infants born to women who were both VDRL and HIV
       seropositive had a lower birthweight than infants of women who were VDRL
       seronegative and HIV seropositive (p = 0.017). We conclude that 1) the
       prevalence of vertical transmission of HIV to the newborn is high in
       Northern Thailand, 2) there is no association between maternal
       nutritional status and vertical transmission, and 3) unlike infants born
       to VDRL seropositive mothers, infants vertically infected with HIV were
       no more likely to be SGA than non-infected infants. We conclude that
       neonatal HIV infection is not necessarily associated with low
       birthweight and that a substantial number of infants with vertical
       infection become infected at or after birth in our population.
 DE    Birth Weight  *Disease Transmission, Vertical  Female  Gestational Age
       Human  HIV Infections/TRANSMISSION  *HIV
       Seropositivity/COMPLICATIONS/TRANSMISSION  Infant, Newborn  Pregnancy
       *Pregnancy Complications, Infectious  Pregnancy Outcome
       Syphilis/COMPLICATIONS  Weight Gain  MEETING ABSTRACT  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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