Document 0607
 DOCN  M95A0607
 TI    Disseminated Mycobacterium bovis (BCG) in a child with HIV infection.
       American Pediatric Society 104th annual meeting and Society for
       Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Ellaurie M; Rakusan T; Gutierrez MP; Sever J; Children's National
       Medical Center, Washington, DC, USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330437
 AB    RD is a 27 month old child from Brazil with perinatal HIV infection who
       presented at 14 months of age with a history of recurrent fever and oral
       thrush, episodic diarrhea, anemia and developmental delay. Physical exam
       revealed oral candidiasis, generalized lymphadenopathy and
       hepatosplenomegaly. Investigations showed esophageal candidiasis,
       cerebral atrophy, cardiomegaly, hepatitis and decreased red cell
       precursors in the bone marrow. The absolute CD4 count was 50/mm3. She
       was started on treatment with ACTG protocol 152 with AZT and/or DDI. At
       2 years of age she was admitted in respiratory distress with
       interstitial pneumonia, spiking fever:, gastroenteritis, and increasing
       abdominal distension and pain with massive hepatosplenomegaly and
       esophageal candidiasis. Radiologic exam revealed an enlarged bile duct
       and mesenteric adenopathy. She had pancytopenia with a hypocellular
       marrow. Platelets were 39,000/mm3, Hb 7 g/dl, ANC 700/mm3. Blood and
       bronchoalveolar lavage cultures were positive for Mycobacterium with the
       HPLC pattern characteristic of M. Bovis (BCG). The patient received BCG
       at one month of age. Treatment with ethambutol, rifampin, INH and
       prelone for thrombocytopenia resulted in clinical improvement.
 DE    *AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY  Case
       Report  Child, Preschool  Female  Human  *Mycobacterium bovis
       *Tuberculosis/DIAGNOSIS/DRUG THERAPY  MEETING ABSTRACT  JOURNAL ARTICLE

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