Document 0610
 DOCN  M95A0610
 TI    Response to trivalent influenza vaccine in children vertically infected
       with HIV. American Pediatric Society 104th annual meeting and Society
       for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Tressler RL; King JC; Batlas S; Stancliff C; Farley JI; Vink PE; Univ.
       of Md. Hosp., Dept. of Pediatrics, Balto., USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330434
 AB    The CDC recommends that all individuals > 6 months of age receive
       trivalent inactivated influenza (Flu) vaccine if they or a household
       member is HIV infected. However, there is limited data on the
       immunologic response to Flu vaccine in HIV-infected children. We report
       data on the serologic response of children exposed to HIV in utero.
       During the fall of 1991 and 1992, 27 HIV infected (mean age 39, range
       6.3 to 97 months) and 18 HIV (-) children born to HIV (+) mothers (mean
       age 36, range 8.2 to 80 months) were recruited and immunized with Flu
       vaccine according to CDC guidelines. Hemagglutination inhibition (HAI)
       titers were measured on sera obtained just prior to and 3 to 16 weeks
       post-vaccination. The change in HAI titers (log2 post - log2 pre) were
       compared between HIV (+) and HIV (-) children using Wilcoxon Rank Sum.
       The proportion of children with > or = 4-fold rise in HAI titers
       (vaccine responders) were compared using Fisher's exact. CDC clinical
       HIV classification (P1 or P2), immunologic parameters (lymphocyte
       subsets and total IgG levels) were compared in HIV positive vaccine
       responders and non-responders using Wilcoxon Rank Sum. The mean rise in
       log2 HAI titers (increases titer) and % with 4-fold increase (% rise) in
       HAI titers are shown below. There was no significant difference between
       Flu vaccine responders and non-responders based upon CDC classification
       or immunologic parameters. TABULAR DATA, SEE PUBLISHED ABSTRACT.
       Although HIV infected children respond to Flu vaccine, as demonstrated
       by rise in HAI titer, the magnitude of the response is significantly
       decreased compared to HIV (-) children. Neither clinical HIV class nor
       immunologic parameters predicted response to Flu vaccine.
 DE    Antibodies, Viral/ANALYSIS  *Disease Transmission, Vertical
       Hemagglutination Inhibition Tests  Human  HIV
       Infections/*IMMUNOLOGY/TRANSMISSION  Infant  Influenza
       Vaccine/*IMMUNOLOGY  Orthomyxovirus Type A, Human/IMMUNOLOGY
       Orthomyxoviruses Type B/IMMUNOLOGY  MEETING ABSTRACT  JOURNAL ARTICLE

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