Document 0614
 DOCN  M95A0614
 TI    An association between HIV infection, Epstein-Barr virus (EBV) immune
       status, cardiomyopathy, and lymphocytic interstitial pneumonia (LIP).
       American Pediatric Society 104th annual meeting and Society for
       Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Valentine M; Tripp M; McKinney RE Jr; Duke University Medical School,
       Dept. of Pediatrics, Infectious; Diseases and Cardiology, Durham, NC,
       USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330430
 AB    Reports have identified an association between co-infection with HIV and
       EBV, and two HIV associated clinical syndromes, cardiomyopathy and LIP.
       Using serologic methods we evaluated the EBV status of our current
       HIV-infected patients between 48 weeks and 12 years old (n = 77).
       Patients were excluded if they had received intravenous immune globulin
       (IVIg) within the last 6 months (n = 12). 9 patients did not have EBV
       results available. The 56 evaluable patients were classified as EBV
       seronegative (n = 8, 14%), EBV infected in the past (n = 31, 55%),
       recently infected (n = 1, 2%), or an incomplete response (positive for
       IgG antibodies to Virus Capsid Antigen (titer > 1:20) and negative for
       anti-Epstein-Barr Nuclear Antigen (EBNA)) (n = 16). Cardiomyopathy was
       determined by clinical evaluation, including EKG and echocardiogram, and
       LIP by typical chest X-ray findings. TABULAR DATA, SEE PUBLISHED
       ABSTRACT. The proportion of patients with LIP who had incomplete
       responses to EBV was significant (p = 0.02 for LIP, Fisher's Exact). A
       high proportion of patients with cardiomyopathy also had an incomplete
       response (p = 0.02, cardiomyopathy vs. no cardiomyopathy). The lack of
       EBNA antibodies during an immune response to EBV is thought to reflect
       either an early response to EBV or a failure to generate specific
       anti-EBV immune effectors. The relationship between this incomplete
       response to EBV, LIP, and cardiomyopathy may reflect a common underlying
       pathogenic mechanism, and is particularly interesting given the
       relatively good prognosis of LIP patients.
 DE    Antibodies, Viral/ANALYSIS  Antigens, Viral/IMMUNOLOGY  AIDS-Related
       Opportunistic Infections/COMPLICATIONS  Capsid/IMMUNOLOGY  Child  Child,
       Preschool  DNA-Binding Proteins/IMMUNOLOGY  Herpesviridae
       Infections/*COMPLICATIONS/DIAGNOSIS  *Herpesvirus 4, Human/IMMUNOLOGY
       Human  HIV Infections/*COMPLICATIONS  Lung Diseases,
       Interstitial/*COMPLICATIONS  Myocardial Diseases/*COMPLICATIONS  Tumor
       Virus Infections/*COMPLICATIONS/DIAGNOSIS  MEETING ABSTRACT  JOURNAL
       ARTICLE

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