Document 0618
 DOCN  M95A0618
 TI    Immunologic changes in the first 6 months of life in subjects born to
       HIV+ women. American Pediatric Society 104th annual meeting and Society
       for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Kovacs A; Pan L; Chan L; Dept of Peds., LAC+USC Medical Center/USC
       School of Medicine,; USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330426
 AB    OBJECTIVE: To determine age related changes of immunologic parameters in
       the first 6 months of life in HIV infected (HIV+) and uninfected (HIV-)
       children born to infected women. METHOD: Immunologic parameters
       including CD3, CD4, CD8, B and non-T non-B (NK) lymphocytes were
       prospectively evaluated in 139 children (36 HIV+ and 103 HIV-) born to
       HIV+ women from 1988 through 1993. Patterns of change with age within
       each group, between the two groups, and among the parameters were
       analyzed. The 6 months net changes were calculated based on the
       measurements at birth. RESULTS: Significant immunologic changes occur in
       the first 6 months of life. CD4 counts decreased from birth to 3 months,
       then increased and peak at 6 months for both HIV+ and HIV- infants.
       However, HIV+ infants consistently had lower mean count after 2 months
       (P < 0.05) and had a greater net decrease of total CD4 cells during the
       first 6 months (HIV+: 19.9% HIV-: 1.3%). The greatest decrease in CD4
       occurred between 1 and 2 month of life for HIV+ infants (477 CD4 cells
       mm3/month). No significant differences were found between the two groups
       in Lymphocyte count, CD8 count, CD3 count, CD3 percent and NK
       lymphocytes. The mean CD8% was the same for both groups at birth. For
       HIV+ group CD8% rose sharply at 2 month and leveled off (6 month net
       increase was 20.7%) while HIV- group had a continuous slight downward
       trend throughout the 6 months (net decrease was 12.3%). Both B cells and
       percent of B lymphocytes rose sharply during the first 6 months of life
       for both groups (B cells: a net increase of 127.8% for infected and
       150.7% for the uninfected; percent of B Lymphocytes: 112.2% and 110.2%
       respectively). CONCLUSION: Significant immunologic changes occur both in
       HIV+ and HIV- infants in the first 6 months of life. Diagnostic
       interpretations and therapeutic approaches in caring for HIV+ children
       during the first 6 month of life must take these changes and differences
       into consideration.
 DE    Age Factors  Antigens, CD3/ANALYSIS  CD4 Lymphocyte Count  CD8-Positive
       T-Lymphocytes  Female  Human  HIV Infections/*IMMUNOLOGY  *HIV
       Seropositivity  Infant  Infant, Newborn  Killer Cells, Natural
       *Lymphocyte Count  *Lymphocyte Subsets  Pregnancy  *Pregnancy
       Complications, Infectious  Prospective Studies  MEETING ABSTRACT
       JOURNAL ARTICLE

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