Document 0619
 DOCN  M95A0619
 TI    Effects of human immunodeficiency virus (HIV) exposure and infection on
       plasma glutathione status in children. American Pediatric Society 104th
       annual and Society for Pediatric Research 63rd annual meeting; 1994 May
       2-5; Seattle.
 DT    9510
 AU    Smith CV; Rogers LK; Rabin RL; Maldonado YA; Herzenberg LA; Herzenberg
       LA; Petru A; Department of Pediatrics, Baylor College of Medicine,
       Houston,; TX, USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330425
 AB    HIV-infected adults have lower glutathione (GSH) concentrations in
       plasma than do healthy controls, suggesting that HIV infection may
       compromise antioxidant defenses and other physiological functions. To
       determine whether HIV infection similarly affects children, we measured
       plasma concentrations of GSH, cysteine (CYS) and cysteinylglycine
       (CYSGLY) in HIV-infected and uninfected children. Plasma concentrations
       of each of the thiols were lower in the infected subjects. Thiol
       concentrations were not different in children with AIDS versus those
       with HIV infections without AIDS. Plasma thiol status was not diminished
       in the infants studied (2-10 months of age) who were vertically exposed,
       but apparently uninfected (PO). TABULAR DATA, SEE PUBLISHED ABSTRACT.
       The mechanisms responsible for lower GSH concentrations are not known,
       but glutathione disulfide concentrations are not increased. The lack of
       an increase in plasma concentrations of CYSGLY does not support the
       hypothesis that elevated gamma-glutamyltranspeptidase activities, which
       often are observed in preneoplastic states, measurably contribute to the
       lower plasma GSH concentrations.
 DE    Adult  Child  Child, Preschool  Cysteine/BLOOD  Dipeptides/BLOOD
       Glutathione/*BLOOD  Human  HIV Infections/*BLOOD  Infant  MEETING
       ABSTRACT  JOURNAL ARTICLE

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