Document 0621
 DOCN  M95A0621
 TI    Quantitation of proteinuria in children with HIV-nephropathy. American
       Pediatric Society 104th annual meeting and Society for Pediatric
       Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Abitbol C; Strauss J; Zilleruelo G; Montane B; Roias E; University of
       Miami/Jackson Memorial Medical Center, Department; of Pediatrics,
       Florida, USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330423
 AB    Accurate assessment of proteinuria in pediatric patients infected with
       the Human Immunodeficiency Virus (HIV) is limited by the constraints
       imposed by timed urine collections in very ill patients. We sought to
       validate the use of random urine specimens to quantitate total protein
       and creatinine excretion in a population of 236 children followed
       prospectively for the development of HIV-nephropathy (HIVN). Creatinine
       clearance (Ccr) was evaluated by the height index formula (Ccr = kL/Pcr)
       with k, a proportionality constant, L body length, and Pcr plasma
       creatinine. Urine total volume (V) was calculated by substituting the
       height index formula into the clearance equation (Ccr = UcrV/Pcr x
       1.73/BSA). The accuracy of the calculation was tested by the regression
       analysis of 23 timed urine specimens from HIV positive patients between
       calculated and measured V (p = 0.86; p < 0.0001). From the 23 timed
       urine collections from HIV(+) patients, total protein excretion (UprV)
       was compared to the Upr/Ucr ratio in 3 regression relationships with
       UprV on the x-axis: linear regression (r = 0.95; y = 2.4x); linear
       regression with the correction factor 0.63 applied to Upr/Ucr (r = 0.95;
       y = 1.5x); and logarithmic regression (r = 0.97; y = x + 0.4). When 143
       random urines from 93 HIV-infected patients were similarly analyzed, the
       logarithmic regression confirmed the relationship with r = 0.99; y = x +
       0.4. Therefore, use of the random Ucr to quantitate proteinuria in
       HIV-infected pediatric patients appears to be valid. It is most
       accurately quantitated by calculating UprV but may also be estimated
       from the Upr/Ucr.
 DE    AIDS-Associated Nephropathy/*URINE  Child  Creatinine/URINE  Human  HIV
       Seropositivity/URINE  Prospective Studies  *Proteinuria  Random
       Allocation  MEETING ABSTRACT  JOURNAL ARTICLE

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