Document 0623
 DOCN  M95A0623
 TI    Characterization of proteinuria in HIV-infected infants. American
       Pediatric Society 104th annual meeting and Society for Pediatric
       Research 63rd annual meeting; 1994 May 2-5; Seattle.
 DT    9510
 AU    Abitol C; Strauss J; Zilleruelo G; Montane B; Roias E; University of
       Miami/Jackson Memorial Medical Center, Department; of Pediatrics,
       Florida, USA.
 SO    Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique
       Identifier : AIDSLINE AIDS/95330421
 AB    At the University of Miami/Jackson Memorial Medical Center between
       January 1986 through June 1993, 236 pediatric patients infected with the
       Human Immunodeficiency Virus (HIV) were followed prospectively for the
       development of HIV-nephropathy (HIVN). One hundred thirty-seven patients
       provided urines for the assessment of proteinuria by urinary protein
       dipstick and urine total protein excretion (UprV). Sixty-seven of the
       137 patients had urines evaluated for microalbuminuria. Characterization
       of significant proteinuria was temporally remote from febrile illness at
       3 tiers of assessment: Albustix > or = 1+ in > or = 2 urines > or = 2
       weeks apart; UprV > or = 0.1 g/m2/d; and microalbuminuria > or = 0.3
       mcg/mg creatinine. The notation of significant proteinuria by
       progressive sensitivity of measurements is shown in the graph.
       Sixty-seven patients had significant proteinuria as determined by
       Albustix. An additional 19 patients were found to have quantitative
       proteinuria exceeding 0.1 g/m2/d. Finally 11 patients were detected to
       have abnormal microalbuminuria who were not detected by the previous
       methods. Distribution of albuminuria for the 68 patients studied was
       divided into the following categories: minimal (< or = 0.3 mcg/mg
       creatinine); intermediate (> 0.3 < 1.0 mcg/mg); and excessive (> or =
       1.0 mcg/mg). Thirty-nine percent (27/68) had intermediate or greater
       range albumin excretion. These data suggest that quantitation and
       characterization of proteinuria by UprV and microalbuminuria may be the
       more sensitive indicators of the development of HIVN in infected
       patients. TABULAR DATA, SEE PUBLISHED ABSTRACT.
 DE    Albuminuria  AIDS-Associated Nephropathy/*DIAGNOSIS  Human  HIV
       Infections/*URINE  Infant  Prospective Studies  *Proteinuria
       Sensitivity and Specificity  MEETING ABSTRACT  JOURNAL ARTICLE

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