Document 0714
 DOCN  M95A0714
 TI    Prognostic value of immunological data, in vitro antibody production,
       and virus culture in vertical infection with HIV-1.
 DT    9510
 AU    Garcia Rodriguez MC; Bates I; de Jose I; Hawkins F; Martinez-Zapico R;
       Ferreira A; Fontan G; Immunology Unit, Hospital La Paz, Madrid, Spain.
 SO    Arch Dis Child. 1995 Jun;72(6):498-501. Unique Identifier : AIDSLINE
       MED/95344239
 AB    The prognostic value of immunological indices, in vitro antibody
       production, and virus culture pattern at 3 months of age was estimated
       in 35 infants infected by HIV-1 from a cohort of 298 babies born to
       HIV-1 seropositive mothers and followed up from birth. At 1 year old, 15
       of these infants were classified as stage P-1 (according to the Centers
       for Disease Control classification) seven were P-2A, and seven had AIDS.
       Significantly higher CD8 percentages, lower percentages and absolute
       value of CD4, and lower CD4/CD8 ratios at 3 months were observed in
       infants with severe symptoms at 1 year of age when compared with those
       who were asymptomatic at this age. Seventy seven per cent of infants
       with a 'rapid' virus culture when 3 months old had developed AIDS or had
       died by 1 year of age and only 8% of those with 'slow' virus culture had
       AIDS when 1 year old. Moreover, 100% of those who were asymptomatic at 1
       year had a slow virus culture at 3 months. Significant statistical
       association was found between the virus replication pattern at 3 months
       and the clinical stage at 1 year of age.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Antibodies,
       Viral/*BIOSYNTHESIS  Cells, Cultured  CD4 Lymphocyte Count  CD4-CD8
       Ratio  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Disease Progression
       *Disease Transmission, Vertical  Follow-Up Studies  Human  HIV
       Infections/*IMMUNOLOGY/TRANSMISSION  HIV-1/*IMMUNOLOGY/PHYSIOLOGY
       Infant, Newborn  Prognosis  Virus Replication  JOURNAL ARTICLE

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