Document 0715
 DOCN  M95A0715
 TI    Effect of resuscitation solutions on the immune status of dogs in
       hemorrhagic shock.
 DT    9510
 AU    Brown E; Lloyd L; Sheth A; Oweis T; Chen JC; Penman L; Mattson JC; Steel
       K; Department of Surgery, St. John Hospital and Medical Center,;
       Detroit, Michigan 48236-2172, USA.
 SO    Am Surg. 1995 Aug;61(8):669-72; discussion 672-3. Unique Identifier :
       AIDSLINE MED/95344104
 AB    The purpose of this study is to examine the effects of three different
       types of fluid resuscitation on the immune system of dogs in hemorrhagic
       shock. Using a modified Wigger shock model, 18 conditioned male dogs
       were bled to mean arterial blood pressure of 60 mm Hg for 90 minutes and
       placed into three groups based on the resuscitative method. Group I:
       Crystalloid Resuscitation; Group II: Autotransfusion; Group III: Banked
       Blood. Laboratory methods for immune status evaluation included total
       lymphocyte count, T4/T8 ratio, total serum immunoglobulins, and
       immunoglobulin electrophoresis. These values were obtained
       pre-hemorrhagic shock, just before resuscitation, and subsequently on
       days 1, 4, and 7. Humoral immunity, represented by total serum
       immunoglobulin levels (IgA, IgG, IgM), was higher in Groups II and III
       when compared with group I on all post-resuscitation days. IgA and IgM
       levels were higher in Group III compared with Groups I and II. IgG level
       was higher in Group II compared with Groups I and III. Cellular immunity
       was also affected by transfusion. Total lymphocyte count was increased
       in Group II on Day 1; however, the three groups were similar with
       respect to this variable on subsequent days. The absolute T4 helper cell
       level in Group II was similar to Groups I and III until Day 7, at which
       time the level became higher in Group II.(ABSTRACT TRUNCATED AT 250
       WORDS)
 DE    Animal  Blood Pressure  Blood Transfusion  Blood Transfusion, Autologous
       Comparative Study  CD4-CD8 Ratio  Dogs  Fluid Therapy  IgA/BLOOD
       IgG/BLOOD  IgM/BLOOD  Immunoelectrophoresis  Immunoglobulins/BLOOD
       Lymphocyte Count  Male  Plasma Substitutes/*THERAPEUTIC USE  Rehydration
       Solutions/*THERAPEUTIC USE  Serum Albumin/ANALYSIS  Shock,
       Hemorrhagic/*IMMUNOLOGY/*THERAPY  T-Lymphocytes,
       Helper-Inducer/PATHOLOGY  T-Lymphocytes, Suppressor-Effector/PATHOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).