Document 0733
 DOCN  M95A0733
 TI    Quantification of lymphadenopathy in experimentally induced feline
       immunodeficiency virus infection in domestic cats.
 DT    9510
 AU    del Fierro GM; Meers J; Thomas J; Chadwick B; Park HS; Robinson WF;
       School of Veterinary Studies, Murdoch University, Australia.
 SO    Vet Immunol Immunopathol. 1995 May;46(1-2):3-12. Unique Identifier :
       AIDSLINE MED/95343529
 AB    Nine cats experimentally infected with feline immunodeficiency virus
       (FIV) and six FIV-negative cats were necropsied to assess the effect of
       FIV infection on lymph nodes. The FIV infected cats were inoculated with
       10(5) TCID50 21-22 weeks previously. The combined weights of all lymph
       nodes and the combined lymph node to organ weight ratios were
       significantly greater in FIV-infected cats when compared to uninfected
       cats. Additionally, by examining all nodes in the body, a regionally
       severe lymphadenopathy in FIV-infected cats was evident involving the
       lymph nodes of the hindlimb, forelimb, and head, in decreasing order of
       severity, with little evidence of enlargement in lymph nodes of the
       alimentary tract. Use of 99% confidence intervals showed that 9/9 FIV
       infected cats had enlarged lymph nodes of the hindlimb and forelimb
       region. In contrast, 7/9 and 3/9 FIV-infected cats exhibited enlargement
       of the nodes of the head region and alimentary tract, respectively.
       Similarly the combined weights of both left and right popliteal lymph
       nodes were enlarged in 9/9 FIV-infected cats whereas 0/6 in uninfected
       cats were not. The enlargement of the popliteal lymph nodes observed at
       necropsy was reflected microscopically by an increase in the size and
       number of germinal centres and an increase in the number of plasma
       cells, especially in the medullary cords. Because of the regional
       variation in lymph node size and numbers, it is suggested that the
       popliteal lymph node is a good indicator node for the assessment of
       lymph node status in FIV infection.
 DE    Animal  Body Weight  Cat Diseases/DRUG THERAPY/*PATHOLOGY  Cats  Cell
       Count  Cyclosporine/ADMINISTRATION & DOSAGE  Feline Acquired
       Immunodeficiency Syndrome/DRUG THERAPY/*PATHOLOGY  Female  Hypertrophy
       *Immunodeficiency Virus, Feline  Lymph Nodes/DRUG EFFECTS/*PATHOLOGY
       Lymphatic Diseases/DRUG THERAPY/PATHOLOGY/*VETERINARY  Male  Organ
       Weight  Specific Pathogen-Free Organisms  Support, Non-U.S. Gov't
       Zidovudine/ADMINISTRATION & DOSAGE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).