Document 0741
 DOCN  M95A0741
 TI    FIV vaccine studies. II. Clinical findings, hematological changes and
       kinetics of blood lymphocyte subsets.
 DT    9510
 AU    Hofmann-Lehmann R; Holznagel E; Aubert A; Bauer-Pham K; Lutz H;
       Department of Internal Veterinary Medicine, University of Zurich,;
       Switzerland.
 SO    Vet Immunol Immunopathol. 1995 May;46(1-2):115-25. Unique Identifier :
       AIDSLINE MED/95343520
 AB    Five groups of cats were vaccinated with different recombinant feline
       immunodeficiency virus (FIV) SU vaccines expressed either in Escherichia
       coli or in the Baculovirus system. In Part I of this series, we
       described the humoral immune response and outcome of intraperitoneal FIV
       challenge exposure. Additionally, all cats were monitored for clinical
       and hematological changes and the course of blood lymphocyte subsets.
       These results are described in this present paper. A great increase of
       antibodies was found after vaccination with different recombinant FIV
       antigens, which did not protect the cats from intraperitoneal FIV
       challenge infection. This observation was paralleled by an increase of
       eosinophils during vaccination which was even more pronounced after
       challenge infection. After FIV challenge, infection lymphadenopathy,
       gingivitis, pharyngitis, changes in total leukocytes and neutrophils and
       a decrease in the CD4+:CD8+ ratio were found in cats of all groups and
       were considered as a sign of the FIV infection taking place, independent
       of vaccination. The following observations suggest that in these cats a
       TH2-like immune response was elicited: the high counts of eosinophils,
       the nature of antigen and adjuvant (aluminium hydroxide) and the high
       amounts of antigens used for immunization. Clearly, this type of immune
       response did not protect the animals from intraperitoneal FIV challenge
       infection.
 DE    Animal  Cats  CD4-CD8 Ratio/VETERINARY  Feline Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY/PATHOLOGY/  PREVENTION & CONTROL  Flow
       Cytometry/VETERINARY  Gingivitis/PATHOLOGY/VETERINARY  Immunodeficiency
       Virus, Feline/GENETICS/*IMMUNOLOGY  Kinetics  Lymphatic
       Diseases/PATHOLOGY/VETERINARY  Lymphocyte Count/VETERINARY  Lymphocyte
       Subsets/*IMMUNOLOGY  Male  Pharyngitis/PATHOLOGY/VETERINARY  Random
       Allocation  Specific Pathogen-Free Organisms  Support, Non-U.S. Gov't
       Th2 Cells/IMMUNOLOGY  Vaccination/VETERINARY  Vaccines,
       Synthetic/IMMUNOLOGY  Viral Envelope Proteins/GENETICS/IMMUNOLOGY  Viral
       Vaccines/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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