Document 0745
 DOCN  M95A0745
 TI    High consumption of fatty fish from the Baltic Sea is associated with
       changes in human lymphocyte subset levels.
 DT    9510
 AU    Hagmar L; Hallberg T; Leja M; Nilsson A; Schutz A; Department of
       Occupational and Environmental Medicine, University; Hospital, Lund,
       Sweden.
 SO    Toxicol Lett. 1995 May;77(1-3):335-42. Unique Identifier : AIDSLINE
       MED/95343423
 AB    Fatty fish from the Baltic Sea accumulate immunotoxic persistent
       organochlorine compounds. In a previous study we found inverse
       correlations between such fish consumption and natural killer (NK) cell
       levels in a Swedish population. The present study concerns 68 Latvian
       subjects with high, low or intermediate fish consumption. High fish
       consumption correlated positively with B cell levels and CD4+/CD8+
       ratios, but negatively with levels of cytotoxic (CD8+) T cells.
       Furthermore, NK cell levels correlated inversely with plasma selenium,
       one of several strong correlates with fish intake. A high fish diet
       includes a set of possible immunomodulating agents. It is presently not
       possible to pinpoint the cause for the observed subset deviations or to
       establish their possible biological importance.
 DE    Adult  Aged  Alcohol Drinking/ADVERSE EFFECTS  Animal
       B-Lymphocytes/DRUG EFFECTS  CD4-CD8 Ratio/DRUG EFFECTS  Dietary
       Fats/*ADVERSE EFFECTS  Fishes  Human  Killer Cells, Natural/DRUG EFFECTS
       Lymphocyte Subsets/*DRUG EFFECTS/*IMMUNOLOGY  Methylmercury
       Compounds/BLOOD/TOXICITY  Middle Age  Selenium/BLOOD/PHARMACOLOGY
       Smoking/ADVERSE EFFECTS  Support, Non-U.S. Gov't  JOURNAL ARTICLE

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