Document 0750
 DOCN  M95A0750
 TI    Lack of interferon gamma receptor beta chain and the prevention of
       interferon gamma signaling in TH1 cells [see comments]
 DT    9510
 AU    Pernis A; Gupta S; Gollob KJ; Garfein E; Coffman RL; Schindler C;
       Rothman P; Department of Medicine, College of Physicians and Surgeons,;
       Columbia University, New York, NY 10032, USA.
 SO    Science. 1995 Jul 14;269(5221):245-7. Unique Identifier : AIDSLINE
       MED/95343350
 CM    Comment in: Science 1995 Jul 14;269(5221):161
 AB    The ability of interferon gamma (IFN-gamma) to inhibit the proliferation
       of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells,
       suggests that helper cell subsets might differ in their activation of
       the IFN-gamma signaling pathway. The IFN-gamma-inducible signal
       transducing factor (STF-IFN gamma) was activated in murine TH2 but not
       in TH1 cell clones, because in the latter the second chain of the
       IFN-gamma receptor (accessory factor 1 or IFN-gamma R beta) was absent.
       Thus, TH1 cells use receptor modification to prevent the activation of
       STF-IFN gamma and achieve an IFN-gamma-resistant state.
 DE    Animal  Base Sequence  Clone Cells  Down-Regulation (Physiology)
       DNA-Binding Proteins/GENETICS/METABOLISM  Gene Expression Regulation
       Interferon Type II/PHARMACOLOGY/*PHYSIOLOGY  Interleukin-4/PHARMACOLOGY
       Mice  Molecular Sequence Data  Phosphoproteins/GENETICS
       Protein-Tyrosine Kinase/METABOLISM  Receptors, Interferon/*PHYSIOLOGY
       *Signal Transduction  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  Th1 Cells/*IMMUNOLOGY/METABOLISM  Th2
       Cells/*IMMUNOLOGY/METABOLISM  Trans-Activators/METABOLISM  JOURNAL
       ARTICLE

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