Document 0758
 DOCN  M95A0758
 TI    Virucidal effects of the steam distillate from Houttuynia cordata and
       its components on HSV-1, influenza virus, and HIV.
 DT    9510
 AU    Hayashi K; Kamiya M; Hayashi T; Department of Virology, Toyama Medical
       and Pharmaceutical; University, Japan.
 SO    Planta Med. 1995 Jun;61(3):237-41. Unique Identifier : AIDSLINE
       MED/95343014
 AB    The steam distillate prepared from fresh plants of Houttuynia cordata
       Thunb. (Saururaceae) was found to have direct inhibitory activity
       against herpes simplex virus type 1 (HSV-1), influenza virus, and human
       immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but
       not against poliovirus and coxsackie-virus. The loss of viral
       infectivity was related to the duration of drug treatment. Three major
       components of the distillate, methyl n-nonyl ketone, lauryl aldehyde,
       and capryl aldehyde, also inactivated HSV-1, influenza virus, and HIV-1.
       These in vitro findings demonstrate that the essential oils provide
       virucidal activity against enveloped viruses by interfering with the
       function of virus envelope.
 DE    Animal  Antiviral Agents/ISOLATION & PURIF/*PHARMACOLOGY  Cell Line
       Cell Survival/DRUG EFFECTS  Dogs  Hela Cells  Herpesvirus 1, Human/*DRUG
       EFFECTS/PHYSIOLOGY  Human  HIV-1/*DRUG EFFECTS/PHYSIOLOGY  Japan  Kidney
       Medicine, Oriental Traditional  Orthomyxovirus Type A, Human/*DRUG
       EFFECTS/PHYSIOLOGY  Plant Extracts/*PHARMACOLOGY  *Plants, Medicinal
       Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

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