Document 0760
 DOCN  M95A0760
 TI    Cytologic diagnosis of anal intraepithelial neoplasia using smears and
       cytyc thin-preps.
 DT    9510
 AU    Sherman ME; Friedman HB; Busseniers AE; Kelly WF; Carner TC; Saah AJ;
       George Washington University School of Medicine, Washington, DC,; USA.
 SO    Mod Pathol. 1995 Apr;8(3):270-4. Unique Identifier : AIDSLINE
       MED/95342893
 AB    To investigate the optimal cytologic method for detecting anal
       intraepithelial neoplasia, the quality and diagnostic findings in 117
       conventionally prepared smears and 191 CYTYC Thin-Preps were compared.
       Samples were obtained with a dacron swab from subjects participating in
       a longitudinal study of gay or bisexual men known as the Study to Help
       the AIDS Research Effort (SHARE). The smear takers were general
       clinicians who had no experience in obtaining cytologic specimens from
       the anus. Smears were entirely satisfactory in 48 (41.0%) subjects,
       limited for interpretation in 41 (35.0%), and unsatisfactory in 28
       (23.9%). CYTYC preparations were satisfactory in 158 (82.7%) cases and
       unsatisfactory in 33 (17.3%). Insufficient cellularity was the most
       frequent reason for both unsatisfactory smears and CYTYC preparations,
       but air drying artifact was present in nearly every smear. Squamous
       intraepithelial lesions (SILs) were detected in four (4.5%) smears
       compared to 53 (33.6%) CYTYC slides. The detection of SIL correlated
       with the presence of glandular and metaplastic cells in CYTYC
       preparations, but this association disappeared if only satisfactory
       specimens were considered. In conclusion, CYTYC Thin-Preps were
       satisfactory twice as often as conventional smears (P < 0.005) and
       detected nearly eight times as many SILs (P < 0.005).
 DE    Anus Neoplasms/*PATHOLOGY  Carcinoma in Situ/*PATHOLOGY  Carcinoma,
       Squamous Cell/*PATHOLOGY  Comparative Study  Cytodiagnosis/STANDARDS
       Cytological Techniques/STANDARDS  Homosexuality, Male  Human  HIV
       Infections/COMPLICATIONS  Longitudinal Studies  Male  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

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