Document 0766
 DOCN  M95A0766
 TI    Frontal cortex indoleamine-2,3-dioxygenase activity is increased in
       HIV-1-associated dementia.
 DT    9510
 AU    Sardar AM; Reynolds GP; Department of Biomedical Science, University of
       Sheffield, UK.
 SO    Neurosci Lett. 1995 Feb 24;187(1):9-12. Unique Identifier : AIDSLINE
       MED/95342528
 AB    HIV-associated dementia is a frequent consequence of HIV infection and
       relates to neuronal damage, possibly as a result of increased neurotoxic
       kynurenine metabolites. Indoleamine-2,3-dioxygenase (IDO) activity,
       which regulates kynurenine metabolism, may thus be increased in HIV
       infection. We measured IDO activity in post-mortem brain tissue from
       AIDS patients, including a subgroup that exhibited dementia, and
       age-matched control subjects. IDO activity was increased, but not
       significantly, in the AIDS group as well as the non-dementia group,
       compared to controls. Enzyme activity was significantly increased in the
       dementia group when compared to control values. IDO activity is
       increased in HIV-associated dementia and is thus likely to increase
       kynurenine pathway metabolites, such as 3-hydroxykynurenine and
       quinolinic acid, and elevated levels of these neurotoxins may contribute
       to the neuronal deficits underlying HIV-associated dementia.
 DE    Acquired Immunodeficiency Syndrome  Adult  Dementia/*METABOLISM  Female
       Frontal Lobe/*PATHOLOGY  Human  HIV-1/*ENZYMOLOGY  Male
       Oxygenases/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).