Document 0776
 DOCN  M95A0776
 TI    Testicular dysfunction in human immunodeficiency virus-infected men.
 DT    9510
 AU    Poretsky L; Can S; Zumoff B; Department of Medicine, Cabrini Medical
       Center, New York, NY; 10010, USA.
 SO    Metabolism. 1995 Jul;44(7):946-53. Unique Identifier : AIDSLINE
       MED/95341981
 AB    This review pertains to gonadal function in men with human
       immunodeficiency virus (HIV) infection, who often exhibit clinical and
       biochemical evidence of hypogonadism. Hypogonadotropic hypogonadism
       appears to be the most commonly encountered abnormality, although
       complete anterior pituitary insufficiency and primary gonadal failure
       have been reported. Levels of sex hormone-binding globulin (SHBG) are
       either unchanged or increased. Plasma levels of estrogens, progesterone,
       androstenedione, dehydroepiandrosterone sulfate (DHEA-S), and prolactin
       vary. Pathologically, except for involvement by opportunistic
       infections, no significant abnormality in the hypothalamic-pituitary
       area has been described, but evidence of orchitis is commonly present.
       The cause(s) of these abnormalities remains unclear. The possible
       factors leading to hypogonadism in HIV-infected men include HIV
       infection itself, opportunistic infections, chronic debilitating
       illness, and effects of cytokines on the hypothalamic-pituitary-gonadal
       axis. Further studies are needed to clarify the cause(s) of testicular
       dysfunction in HIV-infected men and its clinical significance,
       treatment, relevance to the progression of HIV infection, and influence
       on the immune system.
 DE    Human  HIV Infections/*PHYSIOPATHOLOGY  Male  Sex Hormone-Binding
       Globulin/METABOLISM  Support, Non-U.S. Gov't  Testicular Hormones/BLOOD
       Testis/METABOLISM/*PHYSIOPATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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