Document 0783
 DOCN  M95A0783
 TI    [Measuring retinal nerve fiber density with laser polarimetry in
       patients with AIDS in comparison with health probands with reference to
       computer perimetry findings. A pilot study using the nerve fiber
       analyzer]
 DT    9510
 AU    Thierfelder S; Gramer E; Serguhn S; Universitats-Augenklinik Wurzburg.
 SO    Klin Monatsbl Augenheilkd. 1995 Mar;206(3):165-9. Unique Identifier :
       AIDSLINE MED/95341844
 AB    BACKGROUND: Several authors postulated a retinal nerve-fiber loss in
       HIV-infection because of functional alterations (reduced colour
       sensitivity, alterations in perimetry). This hypothesis has been
       reevaluated for the first time by means of direct in-vivo measurement of
       the retinal nerve-fiber-layer thickness by laser polarimetry using the
       Nerve-Fiber-Analyzer. PATIENTS AND METHODS: Retinal nerve-fiber-layer
       thickness in 14 eyes of 7 patients has been compared to equally-sided
       eyes of equally-aged healthy controls. Visual fields showed a bilateral
       diffuse sensitivity reduction in 5 patients. Visual fields of 2 patients
       and all healthy controls were normal. RESULTS: A significant difference
       in measurement values of nerve-fiber-layer thickness did not show
       between AIDS-patients and healthy controls. There was no correlation
       between visual field alterations and measurement values of
       nerve-fiber-layer thickness. CONCLUSION: In AIDS patients, a retinal
       nerve-fiber loss corresponding to their visual-field alterations has not
       been found. However, these visual-field alterations may also be
       explained by central-nervous disorders, lens opacifications or
       neuro-retinal dysfunctions without nerve-fiber loss.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Adult  English Abstract
       Female  Human  Image Processing, Computer-Assisted/*INSTRUMENTATION
       Lasers/*DIAGNOSTIC USE  Male  Middle Age  Nerve Fibers/*PATHOLOGY
       Perimetry/*INSTRUMENTATION  Reference Values  Retina/PATHOLOGY  Retinal
       Diseases/*PATHOLOGY  Signal Processing,
       Computer-Assisted/*INSTRUMENTATION  Visual Fields/PHYSIOLOGY  JOURNAL
       ARTICLE

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