Document 0795
 DOCN  M95A0795
 TI    TCR gamma delta cells: mysterious cells of the immune system.
 DT    9510
 AU    Sciammas R; Tatsumi Y; Sperling AI; Arunan K; Bluestone JA; Department
       of Pathology, Ben May Institute, University of; Chicago, Ill., USA.
 SO    Immunol Res. 1994;13(4):268-79. Unique Identifier : AIDSLINE
       MED/95341110
 AB    Gamma delta cells participate in pathogenic infections and autoimmune
       conditions, yet, almost a decade after their discovery, little is known
       regarding their TCR repertoire or effector functions. Unlike
       MHC-restricted antigen recognition employed by TCR alpha beta cells, TCR
       gamma delta cells can recognize whole unprocessed antigens in an MHC-
       independent manner. The nature of positive and negative selection used
       to shape the repertoire of TCR gamma delta cells is unclear, especially
       in the nonlymphoid tissues where these cells predominate. While TCR
       gamma delta cells express an activated phenotype and are present in
       pathological conditions, their roles in immunological protein is
       unknown. This review will focus on our efforts to study these issues of
       TCR gamma delta biology.
 DE    Animal  Antigen Presentation/*IMMUNOLOGY  Antigens,
       Thy-1/BIOSYNTHESIS/DRUG EFFECTS  Arthritis/CHEMICALLY INDUCED/IMMUNOLOGY
       Collagen/PHARMACOLOGY  Cyclosporine/PHARMACOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY/MICROBIOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY/MICROBIOLOGY  Human  Listeria
       Infections/IMMUNOLOGY  Mice  Mice, Transgenic  Models, Immunological
       Receptors, Antigen, T-Cell, gamma-delta/*IMMUNOLOGY
       Schistosomiasis/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).