Document 0800
 DOCN  M95A0800
 TI    Human immunodeficiency virus and the skin: selected controversies.
 DT    9510
 AU    Duvic M; Department of Dermatology, University of Texas Medical School,;
       Houston, 77030, USA.
 SO    J Invest Dermatol. 1995 Jul;105(1 Suppl):117S-121S. Unique Identifier :
       AIDSLINE MED/95341040
 AB    Acquired immunodeficiency syndrome was first recognized as a new disease
       in 1981 because of the unusual association of Kaposi's sarcoma and
       Pneumocystis carinii pneumonia in young men. The skin remains one of the
       most important clinical markers for acquired immunodeficiency syndrome,
       now recognized as the end stage of infection with the human
       immunodeficiency virus (HIV). Indeed, an urticarial viral exanthem
       appearing during seroconversion may allow early identification of newly
       infected individuals who might benefit from administration of antiviral
       therapy during plasma viremia. The asymptomatic HIV infection is often
       accompanied by multiple skin complaints, which commonly include xerosis,
       pruritus, psoriasis/seborrheic dermatitis, and pruritic papular
       eruptions, the cause of which remains controversial. Psoriasis and
       Kaposi's sarcoma lesions share features including angiogenesis, dermal
       dendrocytes infected with HIV, and epidermal hyperproliferation, and are
       manifested by mice transgenic for HIV provirus or Tat-ltr. Changes in
       the immune system including T-cell function, antigen response, and
       shifting cytokine expression as well as a propensity for autoimmune
       reactions must underlie the skin immunodysfunction occurring in the
       setting of HIV infection. One of the most unsettling controversies
       suggested by in vitro data is that ultraviolet light, an effective
       therapy for HIV-related skin disorders, may actually activate the virus.
 DE    Animal  Autoimmunity  Human  HIV/*PHYSIOLOGY/RADIATION EFFECTS  HIV
       Infections/COMPLICATIONS/IMMUNOLOGY/PATHOLOGY  HIV Seropositivity  Male
       Pruritus/COMPLICATIONS  Reiter's Disease/COMPLICATIONS  Sarcoma,
       Kaposi's/ETIOLOGY  Skin/PATHOLOGY/*VIROLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Syndrome  Ultraviolet Rays  Virus
       Activation  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).