Document 0804
 DOCN  M95A0804
 TI    Thalidomide-resistant HIV-associated aphthae successfully treated with
       granulocyte colony-stimulating factor.
 DT    9510
 AU    Manders SM; Kostman JR; Mendez L; Russin VL; Department of Medicine,
       University of Medicine and Dentistry of; New Jersey, Robert Wood Johnson
       Medical School at Camden, USA.
 SO    J Am Acad Dermatol. 1995 Aug;33(2 Pt 2):380-2. Unique Identifier :
       AIDSLINE MED/95340935
 AB    Thalidomide has been advocated as the treatment of choice for
       recalcitrant aphthae. We describe the case of patient with HIV infection
       and extensive aphthae whose condition failed to respond to
       corticosteroids, cyclosporine, and thalidomide. The patient's course was
       complicated by colonic aphthae. Rapid and sustained resolution was
       achieved through treatment with granulocyte colony-stimulating factor, a
       previously unreported therapeutic option.
 DE    Adult  Case Report  Granulocyte Colony-Stimulating Factor/*THERAPEUTIC
       USE  Human  HIV Infections/*COMPLICATIONS  Stomatitis, Aphthous/*DRUG
       THERAPY/VIROLOGY  Thalidomide/*THERAPEUTIC USE  JOURNAL ARTICLE

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