Document 0811
 DOCN  M95A0811
 TI    Detection of Tropheryma whippelii DNA in a patient with AIDS.
 DT    9510
 AU    Maiwald M; Meier-Willersen HJ; Hartmann M; von Herbay A; Institute of
       Hygiene and Microbiology, University of Heidelberg,; Germany.
 SO    J Clin Microbiol. 1995 May;33(5):1354-6. Unique Identifier : AIDSLINE
       GENBANK/M87484
 AB    A case of an AIDS patient infected with the Whipple's disease bacterium,
       Tropheryma whippelii, is reported. A DNA fragment with sequence
       specificity for the 16S rRNA gene of the bacterium was detected by PCR
       in a duodenal biopsy specimen from a 55-year-old male patient with AIDS
       and diarrhea. The biopsy specimen contained periodic acid-Schiff
       stain-positive macrophages which did not, however, resemble the
       sickleform-particle-containing cells characteristic of Whipple's
       disease. This observation raises two possibilities: either the patient
       had a coincidence of AIDS and Whipple's disease or Tropheryma whippelii
       acted as an opportunistic pathogen in this immunodeficient patient. The
       latter explanation is of interest in light of the ongoing discussion of
       immunologic abnormalities as predisposing factors for Whipple's disease.
 DE    AIDS-Related Opportunistic Infections/COMPLICATIONS/*MICROBIOLOGY/
       PATHOLOGY  Bacterial Infections/COMPLICATIONS/*MICROBIOLOGY/PATHOLOGY
       Case Report  DNA, Bacterial/GENETICS/*ISOLATION & PURIF  Human
       Lipodystrophy, Intestinal/COMPLICATIONS/*MICROBIOLOGY/PATHOLOGY  Male
       Middle Age  Molecular Sequence Data  Polymerase Chain Reaction  RNA,
       Bacterial/GENETICS  RNA, Ribosomal, 16S/GENETICS  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).