Document 0812
 DOCN  M95A0812
 TI    Stability of free and complexed human immunodeficiency virus type 1
       antigen at 4 degrees C and at room temperature.
 DT    9510
 AU    Griffith BP; Garner RB; Chacko TM; Retrovirus Diagnostic Section,
       National Virology Reference; Laboratory, VA Medical Center, West Haven,
       Connecticut 06516,; USA.
 SO    J Clin Microbiol. 1995 May;33(5):1348-50. Unique Identifier : AIDSLINE
       MED/95340777
 AB    Free and immune-complex-dissociated (ICD) human immunodeficiency virus
       type 1 (HIV-1) antigenemias in serum specimens stored at room
       temperature (RT) and 4 degrees C for 1 to 35 days were evaluated. At all
       time points examined, there was no significant loss in detectable levels
       of ICD HIV-1 antigen at either RT or 4 degrees C. Free HIV-1 antigen was
       not stable in serum samples stored at RT for more than 2 days but was
       stable in samples stored at 4 degrees C for up to 4 days. Loss of free
       antigen occurred more rapidly in samples with high antigen content at
       baseline. Use of the ICD antigen assay allowed accurate quantitation of
       antigen in samples stored at RT or 4 degrees C for as long as 1 month.
 DE    Antigen-Antibody Complex/*BLOOD  Cold  Drug Stability  Enzyme-Linked
       Immunosorbent Assay  Human  HIV Antigens/*BLOOD  HIV Infections/VIROLOGY
       HIV-1/*IMMUNOLOGY/ISOLATION & PURIF  In Vitro  Support, U.S. Gov't,
       P.H.S.  Temperature  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).