Document 0813
 DOCN  M95A0813
 TI    Molecular typing of Candida albicans in oral candidiasis: karyotype
       epidemiology with human immunodeficiency virus-seropositive patients in
       comparison with that with healthy carriers.
 DT    9510
 AU    Lupetti A; Guzzi G; Paladini A; Swart K; Campa M; Senesi S; Dipartimento
       di Biomedicina, Sperimentale Infettiva e Pubblica,; Universita degli
       Studi di Pisa, Italy.
 SO    J Clin Microbiol. 1995 May;33(5):1238-42. Unique Identifier : AIDSLINE
       MED/95340753
 AB    Candida albicans organisms isolated from the oral cavities of healthy
       carriers (26 individuals) and compromised hosts (40 human
       immunodeficiency virus [HIV]-seropositive patients, all showing
       symptomatic oral candidiasis) were compared by resolving
       chromosome-sized DNA molecules into electrophoretic karyotypes. Seven-
       to 10-band electrophoretic patterns were obtained, with significant and
       reproducible differences in the distributions of the DNA bands. Seven
       distinct classes were identified and were designated type a (8 bands),
       type b (8 bands), type c (7 bands), type d (9 bands), type x (10 bands),
       type y (10 bands), and type z (9 bands). Four of these (types a to d)
       were the most representative within all of the isolated strains (95.5%),
       and the other three (types x to z) were observed only once in three
       HIV-seropositive individuals (4.5%). Only types b and c were isolated
       from healthy carriers, with the percentage of their isolation being 61.5
       and 38.5%, respectively, while all the described karyotypes were
       isolated from HIV-seropositive patients, with type b being the most
       frequent (45%); this was followed by types c (25%), a (15%), and d
       (7.5%). The prevalence of type b and c karyotypes in HIV-infected
       individuals, as well as in healthy carriers, suggests that commensal
       strains in the oral cavities of healthy individuals may become the
       prevalent agents of subsequent oral candidiasis in compromised
       hosts.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  AIDS-Related Opportunistic
       Infections/*EPIDEMIOLOGY/MICROBIOLOGY  Candida
       albicans/CLASSIFICATION/*GENETICS/ISOLATION & PURIF  Candidiasis,
       Oral/COMPLICATIONS/*EPIDEMIOLOGY/MICROBIOLOGY  Carrier
       State/MICROBIOLOGY  Comparative Study  DNA, Fungal/GENETICS/ISOLATION &
       PURIF  Epidemiology, Molecular  Female  Human  Karyotyping  Male
       JOURNAL ARTICLE

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