Document 0816
 DOCN  M95A0816
 TI    Cluster of oral atypical Candida albicans isolates in a group of human
       immunodeficiency virus-positive drug users.
 DT    9510
 AU    Boerlin P; Boerlin-Petzold F; Durussel C; Addo M; Pagani JL; Chave JP;
       Bille J; Institute of Microbiology, University Hospital, CHUV-BH19SUD,;
       Lausanne, Switzerland.
 SO    J Clin Microbiol. 1995 May;33(5):1129-35. Unique Identifier : AIDSLINE
       MED/95340733
 AB    Twenty-one chlamydospore-forming and germ tube-positive Candida albicans
       clinical isolates from 15 human immunodeficiency virus (HIV)-positive
       and 3 HIV-negative patients were examined by two different genetic
       methods. Multilocus enzyme electrophoresis and hybridization with the C.
       albicans-specific Ca3 probe showed that such isolates can be split into
       two genetically distinct groups that can be clearly distinguished. One
       group mainly contained strains with atypical sugar assimilation patterns
       and could be distinguished from the other group by the absence of
       intracellular beta-glucosidase activity. All 13 strains belonging to
       this group were isolated from the oral cavities of asymptomatic
       HIV-positive drug users and may be less pathogenic than the eight
       strains from the other group isolated either from HIV-positive patients
       with oropharyngeal candidiasis or from HIV-negative patients with
       invasive candidiasis.
 DE    beta-Glucosidase/METABOLISM  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/DIAGNOSIS/  *MICROBIOLOGY  Candida
       albicans/CLASSIFICATION/GENETICS/*ISOLATION & PURIF  Candidiasis,
       Oral/*COMPLICATIONS/DIAGNOSIS/*MICROBIOLOGY  Cluster Analysis
       Enzymes/METABOLISM  Genotype  Human  Phenotype  Substance Abuse,
       Intravenous/COMPLICATIONS/*MICROBIOLOGY  JOURNAL ARTICLE

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