Document 0823
 DOCN  M95A0823
 TI    [Large-cell anaplastic malignant CD30/Ki-1-positive T-type lymphoma,
       associated with STLV-1 virus (baboon malignant lymphoma model]
 DT    9510
 AU    Iakovleva LA; Indzhiia LV; Chikobava MG; Demenkova NP; Klotts IN;
       Shettsl' G; Deinkhardt F; Lapin BA; Medical Microbiology and Hygiene
       Institute, Munchen, Germany.
 SO    Gematol Transfuziol. 1995 Jan-Feb;40(1):10-6. Unique Identifier :
       AIDSLINE MED/95340156
 AB    Large-cell anaplastic malignant lymphoma of T-type (T-LCAL) as an
       original form among human non-Hodgkin's malignant lymphomas in Updated
       Kiel Classification (1988) was defined. In human pathology T-LCAL
       presents a considerable diagnostic difficulties and is not associated
       with HTLV except some cutaneous forms. Comparative examination was
       carried out in 5 cases of baboon T-LCAL as a part of long-term
       investigation of the lymphoma outbreak in Sukhumi monkey stock. In
       tumor-bearing baboons routine morphological methods,
       immuno-morphological phenotyping of lymphoma cells with panel of MoAT
       and polyclonal antibodies to T- and B-lymphoid cell antigens and
       antigens of cell activation, including CD30 antigen, in cell suspension
       and on cryostate sections were used. STLV-provirus integration in DNA of
       lymphoma cells in PCR was determined. Diagnostically important
       morphological features of baboon and human T-LCAL include pronounced
       anaplasia and anisocytosis of CD30-positive large blast cells, tumour
       cell tendency to infiltrate sinuses and vascular walls. The presence of
       T-cell markers (CD2, CD3, CD4, CD8 in our cases) and antigens of cell
       activation (CD25, HLA-DR) were found. In DNA of baboon lymph node
       lymphomas (also in the cases without skin involvement) env- and
       tax-fragments of STLV-1 provirus were detected.
 DE    Animal  Disease Models, Animal  English Abstract  Female  Lymphoma,
       Large-Cell, Ki-1/*VIROLOGY  Lymphoma, T-Cell/*VIROLOGY  Male  Papio
       STLV/*ISOLATION & PURIF  JOURNAL ARTICLE

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