Document 0826
 DOCN  M95A0826
 TI    gp120-induced programmed cell death in recently activated T cells
       without subsequent ligation of the T cell receptor.
 DT    9510
 AU    Foster S; Beverley P; Aspinall R; Department of Medicine, St. Mary's
       Hospital Medical School,; London, GB.
 SO    Eur J Immunol. 1995 Jun;25(6):1778-82. Unique Identifier : AIDSLINE
       MED/95339898
 AB    In most individuals, HIV infection is characterized by a progressive
       decline in the number of peripheral blood CD4+ T lymphocytes, and while
       the number of CD4+ cells is within the normal range, defects in immune
       function are detectable. To date neither the decline in function nor the
       decline in cell number have been satisfactorily explained. Here we
       describe a mechanism which may contribute to the immunodeficiency and
       decline in CD4+ cell numbers in HIV-infected individuals. We show that
       recently activated T cells are susceptible to apoptosis when exposed to
       HIV gp120 in the presence of anti-gp120 antibody.
 DE    Antibodies/PHARMACOLOGY  Apoptosis/*IMMUNOLOGY  Human  HIV Envelope
       Protein gp120/IMMUNOLOGY/METABOLISM  HIV Infections/*IMMUNOLOGY
       Lymphocyte Transformation  Receptors, Antigen, T-Cell/IMMUNOLOGY
       T-Lymphocytes/IMMUNOLOGY/METABOLISM/*PATHOLOGY  JOURNAL ARTICLE

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