Document 0827
 DOCN  M95A0827
 TI    Expression in vivo of CD45RA, CD45RB and CD44 on T cell
       receptor-transgenic CD8+ T cells following immunization.
 DT    9510
 AU    Pihlgren M; Lightstone L; Mamalaki C; Rimon G; Kioussis D; Marvel J;
       Ecole Normale Superieure de Lyon, Laboratoire de Biologie; Moleculaire
       et Cellulaire, France.
 SO    Eur J Immunol. 1995 Jun;25(6):1755-9. Unique Identifier : AIDSLINE
       MED/95339894
 AB    We used mice transgenic for a major histocompatibility complex class
       I-restricted T cell receptor to study the changes of phenotype in vivo
       which follow priming by antigen of CD8 T cells. We show that following
       priming with peptide, CD44 on CD8 T cells is up-regulated. The change of
       phenotype was relatively stable, as primed CD8 cells isolated from
       thymectomized mice 6 weeks after priming still expressed increased
       levels of CD44. CD8 T cells in these mice are still responsive to
       peptide and could represent long-lived primed cells. No down-regulation
       in vivo of the CD45RA or CD45RB isoforms was found, indicating that
       there is a differential regulation of the expression of CD44 and CD45RB
       by activated CD8 transgenic T cells. These results contradict earlier
       studies in vitro which showed that CD8 T cells which have been primed
       earlier belong to the CD45RA- or CD45RB- subset.
 DE    Animal  Antigens, CD45/BIOSYNTHESIS/*IMMUNOLOGY  Carrier
       Proteins/BIOSYNTHESIS/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Immunization  Mice  Mice, Transgenic
       Receptors, Antigen, T-Cell/GENETICS/*IMMUNOLOGY  Receptors, Cell
       Surface/BIOSYNTHESIS/*IMMUNOLOGY  Receptors, Lymphocyte
       Homing/BIOSYNTHESIS/*IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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