Document 0839
 DOCN  M95A0839
 TI    Patterns of Ga-67 citrate accumulation in human immunodeficiency virus
       positive patients with and without Mycobacterium avium intracellulare
       infection.
 DT    9510
 AU    Buscombe JR; Buttery P; Ell PJ; Miller RF; Institute of Nuclear
       Medicine, UCL Medical School, London, UK.
 SO    Clin Radiol. 1995 Jul;50(7):483-8. Unique Identifier : AIDSLINE
       MED/95339674
 AB    Infection with Mycobacterium avium intracellulaire (MAI) is an
       increasingly important problem in patients infected with Human
       Immunodeficiency Virus (HIV). The objective of this study was to
       identify whether specific patterns of accumulation of Ga-67 citrate
       occur in HIV antibody positive patients with disseminated MAI infection.
       A retrospective review of Ga-67 scinigraphy was performed in 18 HIV
       antibody positive patients with MAI and 20 HIV antibody positive
       patients without MAI (who acted as a control group). A wide range of
       abnormalities was seen in both groups of patients and no single
       abnormality was diagnostic of MAI. However MAI was likely (sensitivity
       89%, specificity 70%) in the presence of two or more of the following;
       accumulation of Ga-67 in lymph nodes, paranasal sinuses or colon or
       reduced uptake in the bone marrow. No specific abnormality on Ga-67
       scintigraphy in HIV antibody positive patients enables a diagnosis of
       MAI to be made. Subtle and non specific abnormalities of Ga-67 may be
       the only scintigraphic evidence of active Mycobacterium avium
       intracellulare infection.
 DE    Adult  AIDS-Related Opportunistic Infections/*RADIONUCLIDE IMAGING  Bone
       Marrow/RADIONUCLIDE IMAGING  Citrates/*DIAGNOSTIC USE
       Colon/RADIONUCLIDE IMAGING  Female  Gallium Radioisotopes/*DIAGNOSTIC
       USE  Human  HIV Seropositivity/*RADIONUCLIDE IMAGING  Lymph
       Nodes/*RADIONUCLIDE IMAGING  Male  Mycobacterium avium-intracellulare
       Infection/*RADIONUCLIDE  IMAGING  Paranasal Sinuses/RADIONUCLIDE IMAGING
       Retrospective Studies  JOURNAL ARTICLE

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