Document 0844
 DOCN  M95A0844
 TI    T cells in regenerating feathers of Smyth line chickens with vitiligo.
 DT    9510
 AU    Erf GF; Trejo-Skalli AV; Smyth JR Jr; Department of Biological Sciences,
       Smith College, Northampton,; Massachusetts 01063, USA.
 SO    Clin Immunol Immunopathol. 1995 Aug;76(2):120-6. Unique Identifier :
       AIDSLINE MED/95339603
 AB    Smyth line (SL) chickens exhibit a spontaneous, autoimmune,
       depigmentation (SL vitiligo, SLV) in regenerating feather tissue due to
       the death of pigment cells (melanocytes). It was the purpose of this
       study to characterize mononuclear leukocytes which infiltrate the
       feather as SLV develops. Frozen sections of regenerating features from
       SL and control chickens were labeled with a panel of mAbs specific for
       chicken mononuclear leukocytes. SL chickens were found to have
       significantly greater numbers of T cells in the feather pulp prior to,
       and throughout, the development of SLV. Initially, both SL and control
       chickens had a CD4/CD8 ratio near 1.0 in their feather pulp. Following
       the onset of SLV, the CD4/CD8 ratio in SL chickens dropped below 0.4.
       Throughout the development of SLV, SL chickens had greater proportions
       of T cells with alpha/beta T cell receptors than controls. Histological
       evidence strongly supports an important role for T cells in the
       pathology of SLV.
 DE    Animal  Chickens  CD4-CD8 Ratio  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Feathers/CHEMISTRY/CYTOLOGY/*PHYSIOLOGY  Incidence  Receptors, Antigen,
       T-Cell/ANALYSIS  Regeneration/*IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/*IMMUNOLOGY  Vitiligo/EPIDEMIOLOGY/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).