Document 0857
 DOCN  M95A0857
 TI    Relationship of oral disease to the presence of cytomegalovirus DNA in
       the saliva of AIDS patients.
 DT    9510
 AU    Greenberg MS; Dubin G; Stewart JC; Cumming CG; MacGregor RR; Friedman
       HM; Department of Oral Medicine, School of Dental Medicine,; University
       of Pennsylvania, Philadelphia, USA.
 SO    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):175-9.
       Unique Identifier : AIDSLINE MED/95338933
 AB    Cytomegalovirus is an important pathogen in persons infected with human
       immunodeficiency virus. In this study a thorough oral examination was
       done and blood and urine cultures for cytomegalovirus were obtained from
       a group of 31 patients with acquired immunodeficiency syndrome with CD4
       lymphocyte counts less than 150 cells/mm3. Whole saliva was also
       collected for detection of cytomegalovirus deoxyribonucleic acid (DNA)
       via the polymerase chain reaction. The presence of cytomegalovirus DNA
       in the saliva specimens was not related to the presence of
       cytomegalovirus in the urine, which suggests a local source of
       cytomegalovirus from salivary gland and kidney parenchyma. There was
       also a strong statistical relationship between salivary cytomegalovirus
       DNA and xerostomia (p = 0.0004), which suggests that cytomegalovirus may
       be a cause of salivary gland dysfunction in patients with acquired
       immunodeficiency syndrome with low CD4 counts.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult
       Cytomegalovirus/ISOLATION & PURIF  Cytomegalovirus Infections/*ETIOLOGY
       CD4 Lymphocyte Count  DNA, Viral/ANALYSIS  Female  Human  Male  Middle
       Age  Pilot Projects  Polymerase Chain Reaction  Saliva/*VIROLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Urine/MICROBIOLOGY
       Virus Cultivation  Virus Shedding  Xerostomia/ETIOLOGY/*VIROLOGY
       JOURNAL ARTICLE

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