Document 0860
 DOCN  M95A0860
 TI    Treatment of HIV-related hairy leukoplakia with podophyllum resin 25%
       solution.
 DT    9510
 AU    Gowdey G; Lee RK; Carpenter WM; HIV CARE Program, University of the
       Pacific, School of Dentistry,; San Francisco, Calif., USA.
 SO    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):64-7.
       Unique Identifier : AIDSLINE MED/95338917
 AB    Ten HIV-infected patients who had bilateral hairy leukoplakia on the
       tongue were treated with topical podophyllum resin 25% solution. Only
       one side of the bilateral lesion was treated and the other side served
       as the control and was not treated. The lesions on both the treatment
       and control sides were evaluated at day 2, 7, and 30 by an investigator
       who had not been involved in the initial treatment and had no knowledge
       of which side had been treated. Therefore the treatment side is compared
       with the control side in a single-subject design, single-blind control
       setting. The lesions were judged by the degree of resolution and
       assigned a number of 0 to 4 with 4 indicating the highest degree of
       resolution and 0 indicating no resolution or worsening of the condition.
       The results were analyzed by Student's t test. Significant resolution of
       hairy leukoplakia was noted on the treatment side compared with the
       control side at the 2-, 7-, and 30-day levels; the 2-day results were
       the most significant. Furthermore, the patients reported minimal side
       effects, which included burning sensation, bad or altered taste, and
       pain, that were of mild intensity and short duration. The side effects
       were reported to occur immediately after the topical application.
       Patient tolerance and acceptance were found to be very favorable. No
       systemic side effect was reported. We conclude that single topical
       application of podophyllum resin 25% solution is efficacious in
       producing significant short-term resolution of HIV-related oral hairy
       leukoplakia. We also conclude that it is a safe topical regimen with
       minimal side effects.
 DE    Administration, Topical  Human  HIV Infections/COMPLICATIONS
       Leukoplakia, Hairy/*DRUG THERAPY/ETIOLOGY  Male
       Podophyllin/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Single-Blind
       Method  Tongue Neoplasms/*DRUG THERAPY/ETIOLOGY  CLINICAL TRIAL  JOURNAL
       ARTICLE  RANDOMIZED CONTROLLED TRIAL

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