Document 0867
 DOCN  M95A0867
 TI    Wasting syndrome in AIDS: pathophysiologic mechanisms and therapeutic
       approaches.
 DT    9510
 AU    Weinroth SE; Parenti DM; Simon GL; Department of Medicine, George
       Washington University Medical; Center, Washington, D.C. 20037, USA.
 SO    Infect Agents Dis. 1995 Jun;4(2):76-94. Unique Identifier : AIDSLINE
       MED/95338450
 AB    Wasting syndrome is a common complication of HIV infection and is marked
       by progressive weight loss and weakness, often associated with fever and
       diarrhea. The pathophysiologic mechanisms responsible for this syndrome
       are not well defined, but it is clear that this is a multifactorial
       process in which the relative contribution of individual etiologic
       factors vary among patients. Considerations include inadequate diet,
       malabsorptive phenomena, metabolic derangements, and cytokine activity.
       The onset of opportunistic infections is often accompanied by a
       hypermetabolic state characterized by progressive weight loss. Potential
       cytokines that may promote weight loss in AIDS patients include tumor
       necrosis factor, interleukin-1, interleukin-6, and alpha-interferon. At
       present there is no effective treatment. Multiple therapeutic methods,
       including enteral and parenteral alimentation, appetite stimulants,
       recombinant growth hormone, and cytokine modulators, are currently being
       explored.
 DE    Acetylcysteine/THERAPEUTIC USE  Acquired Immunodeficiency
       Syndrome/*COMPLICATIONS/PHYSIOPATHOLOGY  AIDS-Related Opportunistic
       Infections/METABOLISM/PHYSIOPATHOLOGY  Body Composition
       Cachexia/*ETIOLOGY/PHYSIOPATHOLOGY/THERAPY  Cytokines/METABOLISM  Fatty
       Acids, Omega-3/THERAPEUTIC USE  Human  Hyperlipidemia/METABOLISM
       Thalidomide/THERAPEUTIC USE  Weight Loss  JOURNAL ARTICLE  REVIEW
       REVIEW, ACADEMIC

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