Document 0873
 DOCN  M95A0873
 TI    Progressive interstitial lung disease in a 75 year old woman.
 DT    9510
 AU    Kummer F; Salzmann H; Wieckowski A; Second Medical and Lung Dept,
       Wilhelminenspital der Stadt Wien,; Vienna.
 SO    Monaldi Arch Chest Dis. 1995 Apr;50(2):118-22. Unique Identifier :
       AIDSLINE MED/95338208
 AB    The case of a 75 year old woman with rapidly progressive interstitial
       lung disease is presented. Bronchoalveolar lavage (BAL) was consistent
       with CD8+ cell alveolitis, and computerized tomography revealed features
       of bronchiolitis obliterans organizing pneumonia (BOOP). The patient had
       been on clomipramine (a tricyclic antidepressant) for 9 months prior to
       the onset of disease. Cessation of the drug and very short-term oral
       corticosteroid treatment (prematurely terminated by the patient)
       resulted in complete resolution of clinical symptoms, morphological and
       physiological findings, which remained stable without treatment over the
       following year. A possible drug reaction to clomipramine presenting as
       BOOP is discussed.
 DE    Aged  Bronchiolitis Obliterans Organizing Pneumonia/CHEMICALLY INDUCED/
       *DIAGNOSIS  Bronchoalveolar Lavage Fluid/CYTOLOGY  Case Report
       Clomipramine/ADVERSE EFFECTS  CD8-Positive T-Lymphocytes/PATHOLOGY
       Diagnosis, Differential  Drug Hypersensitivity/ETIOLOGY  Female  Human
       Tomography, X-Ray Computed  JOURNAL ARTICLE

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