Document 0884
 DOCN  M95A0884
 TI    Peptide-mediated immunoregulation.
 DT    9510
 AU    Hetzel C; Hoyne GF; Lamb JR; Department of Biology, Imperial College of
       Science, Technology; and Medicine, London, UK.
 SO    Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):275-7. Unique Identifier
       : AIDSLINE MED/95337754
 AB    Quantitative and qualitative characteristics of the signals received by
       a T cell determine whether receptor ligation results in cell activation,
       cell death, or the induction of antigen-specific non-responsiveness.
       Environmental factors such as the nature of costimulation,
       antigen-presenting cell type, peptide structure and cytokine levels also
       influence the differentiation of CD4+ helper T cells into functionally
       distinct subsets, which now appear pivotal in many immune-mediated
       disorders, including autoimmunity and allergy. Selective manipulation of
       the immune response, such as the functional inactivation or deviation of
       the cytokine secretion patterns of specific T cells, may be an effective
       strategy for immunotherapy.
 DE    Allergens/IMMUNOLOGY/PHARMACOLOGY/*THERAPEUTIC USE  Animal  Antigen
       Presentation  Cats  Cytokines/PHYSIOLOGY  Desensitization,
       Immunologic/*METHODS  Glycoproteins/IMMUNOLOGY/PHARMACOLOGY/THERAPEUTIC
       USE  Human  Hypersensitivity/IMMUNOLOGY/THERAPY  Immune Tolerance/DRUG
       EFFECTS/PHYSIOLOGY  Mice  Peptide
       Fragments/IMMUNOLOGY/PHARMACOLOGY/*THERAPEUTIC USE  Th1 Cells/DRUG
       EFFECTS/*IMMUNOLOGY  Th2 Cells/DRUG EFFECTS/*IMMUNOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).