Document 0885
 DOCN  M95A0885
 TI    Genetic basis of IgE responsiveness: relevance to the atopic diseases.
 DT    9510
 AU    Marsh DG; Neely JD; Breazeale DR; Ghosh B; Freidhoff LR; Schou C; Beaty
       TH; Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224,; USA.
 SO    Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):25-8. Unique Identifier
       : AIDSLINE MED/95337746
 AB    Genetic analysis of 170 subjects in 11 extended Amish families revealed
       evidence for linkage of five markers in chromosome 5q31.1 with a gene
       controlling total serum IgE levels. No linkage was found between these
       markers and specific IgE antibody levels. Analysis of total IgE within a
       subset of 128 IgE-antibody-negative sib pairs confirmed evidence for
       linkage to 5q31.1, especially IL4 (p = 4 x 10(-6)). These and other data
       suggest that IL4 or a nearby gene regulates IgE production in a
       non-antigen-specific (noncognate) fashion and provide evidence for a
       possible link between asthma and the IL4 gene.
 DE    Antibody Formation/GENETICS  Antibody Specificity  Chromosomes, Human,
       Pair 5  Consanguinity  Disease Susceptibility/GENETICS/IMMUNOLOGY
       Ethnic Groups/GENETICS  Gene Expression Regulation  Genetic Markers
       Human  Hypersensitivity, Immediate/*GENETICS/IMMUNOLOGY
       IgE/BIOSYNTHESIS/BLOOD/*IMMUNOLOGY  Interleukin-4/GENETICS/PHYSIOLOGY
       Linkage (Genetics)  Support, U.S. Gov't, P.H.S.  Th2 Cells/IMMUNOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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