Document 0889
 DOCN  M95A0889
 TI    Staphylococcal enterotoxin B affects in vitro IgE synthesis,
       interferon-gamma, interleukin-4 and interleukin-5 production in atopic
       eczema.
 DT    9510
 AU    Neuber K; Steinrucke K; Ring J; Department of Dermatology and
       Allergology, University Hospital; Hamburg, Germany.
 SO    Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):179-82. Unique
       Identifier : AIDSLINE MED/95337721
 AB    Peripheral blood mononuclear cells from patients with atopic eczema (AE)
       stimulated with the 'superantigen' Staphylococcus enterotoxin B (SEB)
       secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE,
       and markedly less interferon-gamma than those from healthy controls. Our
       results support the assumption that SEB produced by S. aureus colonizing
       the skin of patients with AE may induce expansion of IL-4- and
       IL-5-producing Th2 clones, leading to increased IgE synthesis and
       eosinophil activation.
 DE    Antigens, Bacterial/*IMMUNOLOGY  Cells, Cultured  Culture Media,
       Conditioned/CHEMISTRY  Dermatitis, Atopic/BLOOD/*IMMUNOLOGY
       Eczema/*IMMUNOLOGY/PATHOLOGY  Enterotoxins/*IMMUNOLOGY  Human
       IgE/*BIOSYNTHESIS  Interferon Type II/*BIOSYNTHESIS/SECRETION
       Interleukin-4/*BIOSYNTHESIS/SECRETION
       Interleukin-5/*BIOSYNTHESIS/SECRETION  Lymphocyte Transformation/*DRUG
       EFFECTS  Staphylococcus aureus/*IMMUNOLOGY  Superantigens/*IMMUNOLOGY
       Th2 Cells/*IMMUNOLOGY/SECRETION  JOURNAL ARTICLE

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