Document 0890
 DOCN  M95A0890
 TI    Importance of interleukin-4 and interleukin-12 in allergen-induced
       airway changes in mice.
 DT    9510
 AU    Kips JC; Brusselle GG; Joos GF; Peleman RA; Devos RR; Tavernier JH;
       Pauwels RA; Department of Respiratory Diseases, University Hospital
       Ghent,; Belgium.
 SO    Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):115-8. Unique Identifier
       : AIDSLINE MED/95337697
 AB    T helper 2 (Th2)-like cells are thought to play a crucial role in the
       pathogenesis of atopic asthma. In this study, we attempted to evaluate
       the in vivo effect of suppressing Th2 cell development on
       allergen-induced airway changes. Repeated exposure of actively
       sensitized C57Bl/6 mice to aerosolized ovalbumin (OA) causes, in
       comparison to saline-exposed control animals, synthesis of specific IgE,
       increase of eosinophils in bronchoalveolar lavage fluid and airway
       hyperresponsiveness. These effects are not observed in OA-exposed,
       sensitized IL-4-knockout mice. Likewise, these effects are inhibited in
       OA-exposed C57Bl/6 mice treated with IL-12 during initial antigen
       exposure. These results suggest that suppressing Th2 cell development in
       vivo might have profound inhibitory effects on allergen-induced airway
       changes.
 DE    Aerosols  Animal  Bronchoalveolar Lavage Fluid/CYTOLOGY/IMMUNOLOGY
       Carbachol/PHARMACOLOGY  Cell Count  Female  IgE/ANALYSIS  Immunization
       Interleukin-12/*PHYSIOLOGY
       Interleukin-4/DEFICIENCY/GENETICS/*PHYSIOLOGY  Male  Mice  Mice, Inbred
       C57BL  Mice, Knockout  Nasal Provocation Tests  Ovalbumin/ADMINISTRATION
       & DOSAGE/IMMUNOLOGY/TOXICITY  Recombinant Proteins/PHARMACOLOGY
       Respiratory Hypersensitivity/ETIOLOGY/*IMMUNOLOGY/PATHOLOGY
       Serotonin/PHARMACOLOGY  Th2 Cells/DRUG EFFECTS/*IMMUNOLOGY/PATHOLOGY
       JOURNAL ARTICLE

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