Document 0916
 DOCN  M95A0916
 TI    Histopathologic spectrum of AIDS-associated lesions in Maharaj Nakorn
       Chiang Mai Hospital.
 DT    9510
 AU    Bhoopat L; Thamprasert K; Chaiwun B; Attasiri C; Vithayasai P;
       Chaimongkol B; Limpichankit T; Sirisanthana V; Department of Pathology,
       Faculty of Medicine, Chiang Mai; University, Thailand.
 SO    Asian Pac J Allergy Immunol. 1994 Dec;12(2):95-104. Unique Identifier :
       AIDSLINE MED/95336558
 AB    The histopathological alterations in various organs and the presence of
       AIDS-associated lesions were studied in 86 biopsy and 29 necropsy
       specimens of AIDS patients. The most common cancer seen in this study
       were malignant lymphomas (4% of cases) with development of extensive
       extranodal lymphomatous involvement from the outset. Although a
       preponderance of high grade B-cell pathologic subtypes is found in
       AIDS-associated lymphoma, we also report the first case of
       T-lymphoblastic lymphoma with a picture of acute lymphoblastic leukemia
       (T-ALL). Tuberculosis (34% of cases) was the most common opportunistic
       infection presented in tissue sections, and the majority of tissue
       biopsies revealed poorly organized granulomas and extensive necrosis
       with numerous bacilli. Penicilliosis (20% of cases) appeared to be the
       most common cutaneous lesion with multiple organ involvement. The
       involved organs showed a partially anergic tissue reaction characterized
       by poorly formed granulomas with diffuse infiltrate of fungi-laden
       macrophages and lymphoid cell depletion. This organism has to be
       distinguished from Histoplasma capsulatum and other yeast-form fungi.
       Co-existing cytomegalovirus and P. carinii infections were the
       predominant findings in lung necropsy specimens from pediatric patients
       who died from AIDS. A major pathologic feature in this group was diffuse
       alveolar damage stage II to III with heavy loads of organism and
       extensive lymphoplasmacytic infiltration.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY  Adult
       AIDS-Related Opportunistic Infections/ETIOLOGY/IMMUNOLOGY/  *PATHOLOGY
       Cytomegalovirus Infections/ETIOLOGY/IMMUNOLOGY/PATHOLOGY  Hospitals
       Human  Immunophenotyping  Infant  Leukemia, T-Cell,
       Acute/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY  Lung/IMMUNOLOGY/PATHOLOGY  Lung
       Diseases, Fungal/ETIOLOGY/IMMUNOLOGY/PATHOLOGY  Lymph
       Nodes/IMMUNOLOGY/PATHOLOGY  Lymphocyte Subsets/IMMUNOLOGY  Lymphoma,
       AIDS-Related/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY  Penicillium  Pneumocystis
       carinii Infections/ETIOLOGY/IMMUNOLOGY/PATHOLOGY  Thailand/EPIDEMIOLOGY
       Tuberculosis, Pulmonary/ETIOLOGY/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).