Document 0918
 DOCN  M95A0918
 TI    Peripheral blood lymphocyte subsets after allogeneic bone marrow
       transplantation: reconstitution and correlation with the occurrence of
       acute graft-versus-host disease.
 DT    9510
 AU    Chan EY; Chiu EK; So MK; Lie AK; Chan TK; Department of Pathology,
       University of Hong Kong, Queen Mary; Hospital.
 SO    Asian Pac J Allergy Immunol. 1994 Dec;12(2):117-23. Unique Identifier :
       AIDSLINE MED/95336547
 AB    Peripheral blood lymphocyte subsets were enumerated at regular intervals
       during the first year after allogeneic bone marrow transplantation (BMT)
       in 21 Chinese patients. Eight of these patients had acute
       graft-versus-host disease (GVHD) while they were assessed at the time of
       engraftment. Our results show in patients receiving allogeneic BMT: (1)
       T and NK cells were the predominant lymphocyte subsets in the early
       reconstitution stage while B cells were severely depleted; (2) absolute
       numbers of the major lymphocyte subsets normalised in 4-5 months; (3) an
       increased percentage of T cells that expressed the activation antigen
       HLA-DR and a reversed CD4:CD8 ratio were observed throughout the first
       12 months after BMT; (4) patients with acute GVHD had significantly
       higher white cell count and NK cell percentage than those not
       complicated by acute GVHD.
 DE    Acute Disease  Anemia, Aplastic/IMMUNOLOGY/THERAPY  B-Lymphocyte
       Subsets/*IMMUNOLOGY  Bone Marrow Transplantation/*IMMUNOLOGY  CD4-CD8
       Ratio  Flow Cytometry  Graft vs Host Disease/*IMMUNOLOGY  Human  HLA-DR
       Antigens/IMMUNOLOGY  Leukemia/IMMUNOLOGY/THERAPY  Lymphocyte Count
       Multiple Myeloma/IMMUNOLOGY/THERAPY  T-Lymphocyte Subsets/*IMMUNOLOGY
       Transplantation, Homologous  JOURNAL ARTICLE

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