Document 0001 DOCN M95B0001 TI Early detection of catabolic state via change in 13C/12C ratios of blood proteins. DT 9511 AU Hatch KA; Sacksteder KA; Treichel IW; Cook ME; Porter WP; Department of Zoology, University of Wisconsin, Madison 53706,; USA. SO Biochem Biophys Res Commun. 1995 Jul 26;212(3):719-26. Unique Identifier : AIDSLINE MED/95352089 AB We find that induction of catabolic state changes the ratios of carbon 13 to carbon 12 in blood proteins. Diet can be inferred in growing chicks by feather carbon isotope ratios. This suggests an approach for early detection of catabolic state induced in patients with HIV, cancers that induce catabolism, infection onset, sepsis, kidney and liver disease, malnutrition and dietary problems. The technique would also be useful in animal husbandry. DE Animal Blood Proteins/*CHEMISTRY/*METABOLISM Carbon/*ANALYSIS *Carbon Isotopes Chickens Diet Feathers/CHEMISTRY/GROWTH & DEVELOPMENT Female Hemoglobins/CHEMISTRY/METABOLISM Human Male JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).