Document 0003
 DOCN  M95B0003
 TI    Novel mutation in the UL97 gene of a clinical cytomegalovirus strain
       conferring resistance to ganciclovir.
 DT    9511
 AU    Hanson MN; Preheim LC; Chou S; Talarico CL; Biron KK; Erice A;
       Department of Laboratory Medicine, University of Minnesota; Medical
       School, Minneapolis 55455-0392, USA.
 SO    Antimicrob Agents Chemother. 1995 May;39(5):1204-5. Unique Identifier :
       AIDSLINE MED/95351773
 AB    Characterization of a ganciclovir-resistant cytomegalovirus strain from
       a patient with AIDS showed a histidine-to-glutamine change at residue
       520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated
       with impaired phosphorylation of ganciclovir. Transfer of Q520 to a
       recombinant virus resulted in a ganciclovir-resistant phenotype.
 DE    AIDS-Related Opportunistic Infections/MICROBIOLOGY  Base Sequence
       Cytomegalovirus/*DRUG EFFECTS/*GENETICS  Drug Resistance, Microbial
       Ganciclovir/*PHARMACOLOGY  Glutamine/METABOLISM  Histidine/METABOLISM
       Human  Molecular Sequence Data  Mutation/GENETICS  Phenotype  Polymerase
       Chain Reaction  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).