Document 0031
 DOCN  M95B0031
 TI    Mixed-type auto-immune haemolytic anaemia in a patient with HIV
       infection.
 DT    9511
 AU    De Angelis V; Biasinutto C; Pradella P; Errante D; Servizio
       Immunotrasfusionale e Analisi Cliniche, IRCCS Centro di; Riferimento
       Oncologico, Aviano, Italia.
 SO    Vox Sang. 1995;68(3):191-4. Unique Identifier : AIDSLINE MED/95350993
 AB    A young HIV-infected patient presented with a severe auto-immune
       haemolytic anaemia with both warm and cold auto-antibodies, an
       infrequent category of anti-erythrocyte auto-immunity. Serological
       findings were compatible with the presence of a low-titre,
       high-thermal-amplitude anti-I cold-reacting antibody and a pan-reactive
       warm-reactive auto-antibody. Immunochemical characterisation of the warm
       antibody failed to identify any membrane protein acting as auto-antigen.
       This is, to our knowledge, the first reported case of mixed-type
       auto-immune haemolytic anaemia in a patient with HIV infection. Overt
       haemolysis is a very rare complication in HIV-infected patients, despite
       the high prevalence of a positive direct antiglobulin test reported in
       these patients. This suggests that HIV infection is a condition in which
       anti-erythrocyte auto-immunity is a serological finding without
       haemolytic effects in the large majority of cases.
 DE    Adult  Anemia, Hemolytic, Autoimmune/COMPLICATIONS/*IMMUNOLOGY
       Autoantibodies/*BLOOD  Case Report  Human  HIV
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  Male  Prevalence  JOURNAL
       ARTICLE

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