Document 0046
 DOCN  M95B0046
 TI    Psychosocial group intervention and the rate of decline of immunological
       parameters in asymptomatic HIV-infected homosexual men.
 DT    9511
 AU    Mulder CL; Antoni MH; Emmelkamp PM; Veugelers PJ; Sandfort TG; van de
       Vijver FA; de Vries MJ; Helen Dowling Institute for Biopsychosocial
       Medicine, Rotterdam,; The Netherlands.
 SO    Psychother Psychosom. 1995;63(3-4):185-92. Unique Identifier : AIDSLINE
       MED/95350312
 AB    The aim of the study was to determine changes in the rate of decline of
       immunological parameters after psychosocial group intervention. Subjects
       were 26 asymptomatic HIV-infected homosexual men who participated in a
       cognitive-behavioral group therapy (CBT; n = 14), or an experiential
       group therapy program (ET; n = 12), both of 15 weeks duration. The
       outcome measures were changes in the decline of CD4 cell counts, and T
       cell proliferative responses to anti-CD3 monoclonal antibodies from
       preintervention to 24 months postintervention. No differences in the
       rate of decline of CD4 cells or T cell responses between the CBT and ET
       condition were found, and there were no significant changes in CD4 cell
       count from pre- to postintervention. However, those subjects who showed
       larger decreases in distress showed a smaller decline in CD4 cell
       counts. While the rate of decline in T cell responses was significantly
       less after both interventions, a similar positive change in T cell
       responses was found in a comparison group of 149 HIV-infected men with
       similar demographic, psychosocial and immunological characteristics who
       did not participate in one of the interventions. We conclude that the
       psychosocial intervention programs tested here did not cause changes in
       CD4 cell decline or T cell responses and that decreases in distress were
       related to increases in CD4 cell counts.
 DE    Adaptation, Psychological  Adult  *Cognitive Therapy  CD4 Lymphocyte
       Count  Homosexuality, Male/PSYCHOLOGY  Human  HIV
       Infections/IMMUNOLOGY/*PSYCHOLOGY  HIV
       Seropositivity/IMMUNOLOGY/PSYCHOLOGY  Lymphocyte
       Transformation/IMMUNOLOGY  Male  Middle Age  *Psychotherapy, Group
       *Sick Role  Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY  CLINICAL
       TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

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