Document 0047
 DOCN  M95B0047
 TI    Inactivation of simian immunodeficiency virus by hydrostatic pressure.
 DT    9511
 AU    Jurkiewicz E; Villas-Boas M; Silva JL; Weber G; Hunsmann G; Clegg RM;
       Abteilung Virologie und Immunologie, Deutsches Primatenzentrum; GmbH,
       Gottigen, Germany.
 SO    Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6935-7. Unique Identifier :
       AIDSLINE MED/95350185
 AB    The inactivation of the simian immunodeficiency viruses SIVmac251 and
       SIVagm by pressures of 150 and 250 MPa was determined. The extent of
       inactivation depended on the time that the virus was subjected to
       compression as well as the level of the pressure and at 150 Mpa reached
       5 log10 dilution units after approximately 10 hr. The inactivations,
       which were uniformly carried out at room temperature, were independent
       of the concentration of the virus. Possible applications of pressure
       inactivation for molecular biological and clinical use are discussed.
 DE    Comparative Study  *Hydrostatic Pressure  Sterilization/*METHODS
       Support, Non-U.S. Gov't  *SIV  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).