Document 0070
 DOCN  M95B0070
 TI    Vesnarinone inhibits nucleoside and nucleobase transport.
 DT    9511
 AU    Kumakura T; Takase K; Terada N; Gelfand EW; Department of Pediatrics,
       National Jewish Center for Immunology; and Respiratory Medicine, Denver,
       CO 80206, USA.
 SO    Life Sci. 1995 Jun 30;57(6):PL75-81. Unique Identifier : AIDSLINE
       MED/95349329
 AB    Vesnarinone is a novel synthetic oral inotropic agent that has been
       successfully used for treatment of patients with congestive heart
       failure. In addition to its cardiotonic activity, the drug has been
       proposed to have mild cytostatic and anti-HIV-1 effects. We have
       observed that vesnarinone profoundly inhibits radiolabeled thymidine and
       uridine incorporation into cells despite its modest inhibitory effect on
       DNA synthesis, RNA synthesis or cell proliferation. Here we demonstrate
       that vesnarinone inhibits both nucleoside and nucleobase transport in
       mammalian cells. This pharmacological action may be involved in some of
       its multiple biological effects.
 DE    Adenine/METABOLISM  Animal  Biological Transport/DRUG EFFECTS  Cell Line
       CHO Cells  Hamsters  Human  Nucleosides/*METABOLISM
       Quinolines/*PHARMACOLOGY  Support, Non-U.S. Gov't  Thymidine/METABOLISM
       Uracil/METABOLISM  Uridine/METABOLISM  JOURNAL ARTICLE

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