Document 0084
 DOCN  M95B0084
 TI    [Morbidity and mortality associated with chronic viral hepatopathy in
       patients infected with the human immunodeficiency virus]
 DT    9511
 AU    Soriano V; Garcia-Samaniego J; Bravo R; Valencia E; Laguna F; de
       Pouplana M; Iniguez A; Munoz F; Gonzalez-Lahoz J; Servicio de
       Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
 SO    Med Clin (Barc). 1995 May 6;104(17):641-4. Unique Identifier : AIDSLINE
       MED/95349185
 AB    BACKGROUND: Hepatitis B, C and D virus infection is frequent in
       HIV-infected individuals, particularly in drug addicts. However, chronic
       liver disease of viral etiology has been little studied in AIDS.
       METHODS: The impact of infection by hepatotropic viruses on hospital
       morbidity/mortality was analyzed in a group of HIV positive (HIV+)
       patients over the period from October 1991 to April 1994. RESULTS: Viral
       liver disease was the cause of hospitalization in 94 (8.6%) out of 1,082
       HIV+ patient admissions. Only 4 admissions were for severe or fulminant
       cases of acute viral hepatitis. Complicated (gastrointestinal bleeding,
       and spontaneous bacterial infection) or decompensated (ascites, jaundice
       and encephalopathy) viral liver disease was the diagnosis in the 90
       remaining cases. Death directly associated to liver diseases was
       observed in 9 (9.5%) of these patients, globally representing 4.3% (9
       out of 207) of the causes of hospital mortality during the study period,
       and the fifth in order of frequency. Hospital stay was significantly
       longer in patients admitted for decompensated or complicated chronic
       viral liver disease in comparison with the remaining patients (27.9 +/-
       9 versus 18.4 +/- 8 days) (p < 0.05). Infection by the hepatitis C virus
       was observed in 88% (80 out of 90) of the hospital admissions for
       chronic liver disease although half presented coinfection by B or delta
       viruses. CONCLUSIONS: Chronic liver disease of viral etiology, mainly by
       the hepatitis C virus, represents an important cause of hospital
       morbidity and mortality in Spanish HIV+ patients.
 DE    Adult  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/*EPIDEMIOLOGY/  ETIOLOGY  Chi-Square
       Distribution  Chronic Disease  English Abstract  Hepatitis, Viral,
       Human/COMPLICATIONS/*EPIDEMIOLOGY/ETIOLOGY  Hospital Mortality
       Hospitalization/STATISTICS & NUMER DATA  Human  *HIV-1  Length of
       Stay/STATISTICS & NUMER DATA  Male  Middle Age  Spain/EPIDEMIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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