Document 0091
 DOCN  M95B0091
 TI    A novel phorbol ester from Excoecaria agallocha.
 DT    9511
 AU    Erickson KL; Beutler JA; Cardellina JH 2nd; McMahon JB; Newman DJ; Boyd
       MR; Laboratory of Drug Discovery Research and Development, National;
       Cancer Institute, NCI-FCRDC, Maryland 21702-1201, USA.
 SO    J Nat Prod. 1995 May;58(5):769-72. Unique Identifier : AIDSLINE
       MED/95348715
 AB    The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) {1} was
       isolated as the anti-HIV principle of Excoecaria agallocha leaves and
       stems collected in northwest Australia. The structure was determined by
       spectral means. Compound 1 was also a potent displacer of [3H]-phorbol
       dibutyrate from rat brain membranes.
 DE    Animal  Antiviral Agents/CHEMISTRY/*ISOLATION & PURIF/PHARMACOLOGY
       Chromatography, Liquid  HIV-1/DRUG EFFECTS/PHYSIOLOGY  Nuclear Magnetic
       Resonance  Phorbol Esters/CHEMISTRY/*ISOLATION & PURIF/PHARMACOLOGY
       Plants, Medicinal/*CHEMISTRY  Rats  Spectrum Analysis, Mass/METHODS
       Virus Replication/DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).